Open Access<p><em>ANGPTL8</em> Gene Polymorphism rs2278426 Is Related to Carotid Intima–Media Thickness in T2DM</p>
Author(s) -
Chen Guo,
Li Zhao,
Yi Ding,
Zhicong Zhao,
Chenxi Wang,
Lian Li,
Zhensheng Cai,
Yanyan Li,
Hong Xia,
ZhuanZhuan Zhu,
Yu Fan,
Meiqing Dai,
Xia Deng,
Guoyue Yuan
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s274759
Subject(s) - medicine , insulin resistance , endocrinology , genotype , intima media thickness , type 2 diabetes mellitus , thickening , waist–hip ratio , allele , adipose tissue , diabetes mellitus , gastroenterology , insulin , waist , body mass index , carotid arteries , biology , gene , chemistry , genetics , polymer science
ANGPTL8 is a cytokine expressed and secreted by liver and adipose tissue, and is involved in glucose, lipid, and energy metabolism. Although studies have shown that ANGPTL8 is elevated in type 2 diabetes mellitus (T2DM) and cardiovascular disease, few have examined the association between ANGPTL8 single-nucleotide polymorphisms and the risk of macrovascular complications in T2DM patients. This study aimed to explore the relationship between rs2278426 and carotid intima-media thickening (cIMT) in T2DM.