Open AccessmiR145 Regulates the Proliferation and Apoptosis of Rat Vascular Endothelial Cells under Hyperglycemia by Targeting the ANGPT2 Gene and Involving the NFκB Signaling Pathway
Author(s) -
Wen Zhang,
Xiaoning Tang,
Jinjuan Zhang,
Quan He
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s273451
Subject(s) - apoptosis , signal transduction , transfection , population , microbiology and biotechnology , flow cytometry , cancer research , biology , western blot , viability assay , cell growth , medicine , gene , biochemistry , environmental health
A majority of diabetes mellitus patients with disturbances of glucose metabolism present with vascular complications. This study aimed to explore regulatory mechanisms of miR145 and its potential target gene ANGPT2 on diabetic vasculopathy under hyperglycemia.