Open Access<p>Renoprotective Effect of Formononetin by Suppressing Smad3 Expression in Db/Db Mice</p>
Author(s) -
Jiawei Lv,
Kai Zhuang,
Xiyu Jiang,
Heqing Huang,
Shijian Quan
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s272147
Subject(s) - formononetin , diabetic nephropathy , endocrinology , fibrosis , medicine , kidney , glomerulosclerosis , chemistry , oxidative stress , ctgf , nephropathy , renal function , diabetes mellitus , growth factor , proteinuria , receptor , daidzein , genistein
Glomerular sclerosis and renal interstitial fibrosis are the most important pathologies in the development of kidney damage under diabetic conditions. Smad3 plays antagonistic roles in high glucose-induced renal tubular fibrosis, which is an important treatment target for diabetic nephropathy (DN). Formononetin (FMN) has multiple effects on diabetic vascular complications including DN. However, whether it plays an anti-fibrosis role by regulating smad3 is unclear. The purpose of this study was to evaluate the renoprotective effect of FMN by suppressing smad3 expression in db/db mice.