Open Access<p>Interference of Hsa_circ_0003928 Alleviates High Glucose-Induced Cell Apoptosis and Inflammation in HK-2 Cells via miR-151-3p/Anxa2</p>
Author(s) -
Ling An,
Dongde Ji,
Wenbo Hu,
Jianrong Wang,
Xiuzhen Jin,
Yue Qu,
Ning Zhang
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s265543
Subject(s) - gene knockdown , apoptosis , viability assay , transfection , microbiology and biotechnology , tunel assay , chemistry , downregulation and upregulation , inflammation , diabetic nephropathy , biology , cell culture , endocrinology , kidney , immunology , gene , biochemistry , genetics
Diabetic nephropathy (DN) is a severe end-stage kidney disease developed from diabetes mellitus. The involvement of circular RNA (circRNAs) in the regulation of DN pathogenesis has been implied, but the underlying mechanism of DN is still lacking. This study aimed to investigate the effect of hsa_circ_0003928 on the inflammation and apoptosis of high glucose (HG)-induced renal tubular cells.