Open Access<p>NLRP3 Blockade Suppresses Pro-Inflammatory and Pro-Angiogenic Cytokine Secretion in Diabetic Retinopathy</p>
Author(s) -
Guangrui Chai,
Shu Liu,
Hongwei Yang,
Guiqiang Du,
Xiaolong Chen
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s264215
Subject(s) - inflammasome , diabetic retinopathy , small hairpin rna , inflammation , vascular endothelial growth factor , medicine , angiogenesis , cytokine , gene silencing , proinflammatory cytokine , tumor necrosis factor alpha , pharmacology , endocrinology , cancer research , diabetes mellitus , gene knockdown , chemistry , apoptosis , vegf receptors , biochemistry , gene
Inflammation and angiogenesis are the two dominant mechanisms of diabetic retinopathy (DR), which act more as mutual pathways rather than individual processes. However, the underlying mechanism of their interactions is still unclear. Here, we explored the potential crossing points between these pathways and the targeted therapeutic method in rats with DR.