Open Access<p>Repurposing Disulfiram as an Anti-Obesity Drug: Treating and Preventing Obesity in High-Fat-Fed Rats</p>
Author(s) -
Ziad Omran,
Ryan A. Sheikh,
Othman A. Baothman,
Mazin A. Zamzami,
Mohamed Alarjah
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s254267
Subject(s) - medicine , disulfiram , drug , pharmacology , obesity , drug repositioning , body weight , weight gain , weight loss , repurposing , endocrinology , biology , ecology
A drug repurposing strategy is an approach for identifying new therapeutic uses for approved or investigational drugs. Thanks to the moderate cost of repurposing a drug compared to bringing new chemical entity to the market, drug repurposing is rapidly gaining ground. The aim of this work is to study the anti-obesity effect of disulfiram (DSF), an irreversible aldehyde dehydrogenase inhibitor approved by the Food and Drug Administration (FDA) to treat chronic alcoholism since 1951.