Open Access<p>Increase in Tryptase and Its Role in the Synovial Membrane of Overweight and Obese Patients with Osteoarthritis of the Knee</p>
Author(s) -
Ken Takata,
Katsuhisa Uchida,
Manabu Mukai,
Shotaro Takano,
Jun Aikawa,
Dai Iwase,
Hiroyuki Sekiguchi,
Masayuki Miyagi,
Gen Inoue,
Masashi Takaso
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s253147
Subject(s) - tryptase , medicine , osteoarthritis , synovial fluid , endocrinology , overweight , cd14 , immunology , body mass index , pathology , mast cell , alternative medicine , receptor
The mechanisms governing evidence that obesity is a risk factor for osteoarthritis (OA) are not well understood. We previously reported an increase in mast cell (MC) marker expression in the osteoarthritic synovial membrane (SM) of patients with obesity. We hypothesized that an enzyme produced by MC, β-tryptase, may be increased in the SM of obese patients with knee OA and contribute to synovial inflammation. This study investigated the expression of the β-tryptase encoding gene, TPSB2 , in the SM of obese patients with knee OA and β-tryptase-mediated regulation of IL-1β in synovial cells.