Open Access<p>STEAP4 Inhibits HIF-1α/PKM2 Signaling and Reduces High Glucose-Induced Apoptosis of Retinal Vascular Endothelial Cells</p>
Author(s) -
Lei Liu,
Hui Xu,
Hongyu Zhao,
Chunying Jiang
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s251663
Subject(s) - apoptosis , western blot , flow cytometry , cell , diabetic retinopathy , inflammation , retinal , retina , endothelial stem cell , chemistry , cancer research , microbiology and biotechnology , medicine , biology , immunology , diabetes mellitus , endocrinology , biochemistry , neuroscience , in vitro , gene
Diabetic retinopathy (DR) is a vascular lesion induced by high glucose. STEAP4 is an indispensable membrane protein, which is closely related to hyperglycemic-induced cell inflammation and injury, while STEPT4 has not been studied in hyperglycemic-induced retinal vascular endothelial cell injury.