Open Access<p>The Role of PPARδ Agosnist GW501516 in Rats with Gestational Diabetes Mellitus</p>
Author(s) -
Jun Zhou,
Ruilian Zhe,
Xiaohui Guo,
Yuying Chen,
Yan Zou,
Li Zhou,
Zhijian Wang
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s251491
Subject(s) - endocrinology , medicine , insulin resistance , gestational diabetes , islet , carbohydrate metabolism , biology , diabetes mellitus , agonist , insulin , gestation , pregnancy , receptor , genetics
Gestational diabetes mellitus (GDM) is a disorder of glucose metabolism that occurs or is found for the first time during pregnancy. GDM is very harmful and urgently needs drug treatment to improve pregnancy outcome. PPARδ is involved in a variety of biological processes related to glycolipid metabolism in the body, suggesting that it may be closely related to insulin resistance and impaired glucose tolerance. The role of PPARδ agonist GW501516 in gestational diabetes has not been studied.