Open Access<p>Alpha1-Antitrypsin in Urinary Extracellular Vesicles: A Potential Biomarker of Diabetic Kidney Disease Prior to Microalbuminuria</p>
Author(s) -
Jing Ning,
Zhicong Xiang,
Chengliang Xiong,
Qin Zhou,
Xin Wang,
Hequn Zou
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s250347
Subject(s) - microalbuminuria , medicine , biomarker , diabetes mellitus , renal function , kidney , urinary system , kidney disease , pathology , endocrinology , biology , biochemistry
Diabetic kidney disease (DKD), which is related to inflammation and immune response, is the primary vascular complication of diabetes mellitus and also the leading etiology of end-stage renal disease. Urinary extracellular vesicles (UEVs) are an attractive source for biomarker detection as they involve molecular constituents derived from their parental sections of the nephron. In this study, we aimed to search for a potential biomarker in UEVs for the early diagnosis and prediction of DKD, especially before the emergence of microalbuminuria.