Open Access<p>Serum LPS and CD163 Biomarkers Confirming the Role of Gut Dysbiosis in Overweight Patients with NASH</p>
Author(s) -
Maha A. Hegazy,
Sherif Mogawer,
Alshaimaa R. Alnaggar,
Olfat A Ghoniem,
Rasha M. Abdel Samie
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s249949
Subject(s) - gastroenterology , medicine , cd163 , overweight , dysbiosis , liver biopsy , steatosis , inflammation , obesity , endocrinology , biopsy , biology , macrophage , biochemistry , disease , in vitro
Gut-microbiota alterations and bacterial translocation might attribute to hepatic inflammation. Lipopolysaccharide stimulates toll-like receptor 4 leading to the activation of Kupffer cells which express the surface receptor, CD 163.