Open Access<p>Effects of Adiponectin on T2DM and Glucose Homeostasis: A Mendelian Randomization Study</p>
Author(s) -
Zefeng Chen,
Yulan Bai,
Xinyang Long,
Qianqian Luo,
Zheng Wen,
Yuanfan Li,
Shengzhu Huang,
Yifei Yan,
Zengnan Mo
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s248352
Subject(s) - mendelian randomization , adiponectin , insulin resistance , confounding , glucose homeostasis , medicine , odds ratio , type 2 diabetes mellitus , type 2 diabetes , endocrinology , confidence interval , diabetes mellitus , insulin , biology , genetics , genotype , genetic variants , gene
The associations of adiponectin with type 2 diabetes mellitus (T2DM), glucose homeostasis (including β-cell function index (HOMA-β), insulin resistance (HOMA-IR), fasting insulin (FI) and fasting glucose (FG)) have reported in epidemiological studies. However, the previous observational studies are prone to biases, such as reverse causation and residual confounding factors. Herein, a Mendelian Randomization (MR) study was conducted to determine whether causal effects exist among them.