Open Access<p>Kukoamine B Ameliorate Insulin Resistance, Oxidative Stress, Inflammation and Other Metabolic Abnormalities in High-Fat/High-Fructose-Fed Rats</p>
Author(s) -
Quan Zhao,
Linhai Li,
Yu Zhu,
Dong Hou,
Yuejin Li,
Xiaodong Guo,
Yongzhi Wang,
Opeyemi Joshua Olatunji,
Ping Wan,
Ke Gong
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s247844
Subject(s) - insulin resistance , medicine , endocrinology , oxidative stress , glutathione peroxidase , malondialdehyde , insulin , superoxide dismutase , chemistry
Obesity is characterized by excessive body fat, insulin resistance and dyslipidemia, which increases the chances of developing chronic diseases like type 2 diabetes, cardiovascular diseases, hypertension, nonalcoholic fatty liver diseases, some types of cancers and neurodegenerative diseases. Kukoamine B (Kuk B) is a spermine alkaloid obtained from Lycium chinense, and it has been shown to possess antidiabetic, antioxidant and anti-inflammatory properties. In this study, we evaluated the therapeutic effect of Kuk B on high-fat diet/high-fructose (HFDFr)-induced insulin resistance and obesity in experimental rats.