Open Access<p>Sennoside A Induces GLP-1 Secretion Through Activation of the ERK1/2 Pathway in L-Cells</p>
Author(s) -
Li Ma,
Xinyu Cao,
Xiaotong Ye,
Jianping Ye,
Yongning Sun
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s247251
Subject(s) - secretion , medicine , endocrinology , western blot , glucagon like peptide 1 , extracellular , insulin , prohormone convertase , chemistry , biology , diabetes mellitus , prohormone , type 2 diabetes , hormone , biochemistry , gene
Glucagon-like peptide-1 (GLP-1) is secreted from the intestinal L-cells to stimulate insulin secretion in the blood glucose control. Our previous study indicates that Sennoside A (SA) can increase the plasma GLP-1 level in a mouse model of type 2 diabetes. However, the mechanism of SA activity remains largely unknown. This issue was explored in this study.