Open Access<p>MicroRNAs and Risk Factors for Diabetic Nephropathy in Egyptian Children and Adolescents with Type 1 Diabetes</p>
Author(s) -
Shereen Abdelghaffar,
Hassan Shora,
Sahar Abdelatty,
Fatma ElMougy,
Riham El Sayed,
Heba Abdelrahman,
Hisham M. Soliman,
HebatAllah Fadel Algebaly,
Sonia Ahmed,
Peter Alfy,
Yasmine Elshiwy
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s247062
Subject(s) - diabetic nephropathy , medicine , creatinine , microrna , cystatin c , type 2 diabetes , diabetes mellitus , nephropathy , endocrinology , renal function , real time polymerase chain reaction , urinary system , oncology , biology , gene , genetics
Currently available markers for early detection of diabetic nephropathy (DN), the leading cause of end stage renal disease, have some limitations. There is insufficient evidence from previous studies about the role of several circulating microRNAs (miRNAs) in the early development of DN. This study aimed to describe the expression of miRNA-377, miRNA-93, miRNA-25, miRNA-216a, and miRNA-21 in a sample of type 1 diabetic children and adolescents to explore their association with DN and some indices of kidney injury.