Open Access<p>Effects of Hydroxysafflor Yellow A on the PI3K/AKT Pathway and Apoptosis of Pancreatic β-Cells in Type 2 Diabetes Mellitus Rats</p>
Author(s) -
Maosheng Lee,
Huilin Li,
Hengxia Zhao,
Suo Miao,
De-liang Liu
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s246381
Subject(s) - medicine , endocrinology , streptozotocin , triglyceride , insulin , metformin , diabetes mellitus , insulin resistance , glycogen , protein kinase b , type 2 diabetes mellitus , blood sugar , apoptosis , cholesterol , biology , biochemistry
Type 2 diabetes mellitus (T2DM), a complex metabolic disease, has become a major public health issue around the world. Hydroxysafflor yellow A (HSYA) is the major active chemical ingredient of Carthamus tinctorius L . (safflower), which is widely used in patients with cardiovascular and cerebrovascular diseases in China. The aim of this study was to investigate the anti-diabetic effect and potential mechanism of HSYA on the high-fat diet (HFD) and streptozotocin (STZ-)-induced T2DM rats.