Open Access<p>Promotion of Adropin Expression by Hyperglycemia Is Associated with STAT3 Activation in Diabetic Rats</p>
Author(s) -
Feng Yu Kuo,
KaiChun Cheng,
Yingxiao Li,
JueiTang Cheng,
Cheng-Chia Tsai
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s243755
Subject(s) - stat3 , endocrinology , medicine , gene knockdown , small interfering rna , streptozotocin , chemistry , glucose homeostasis , stat protein , carbohydrate metabolism , insulin , diabetes mellitus , signal transduction , apoptosis , biology , insulin resistance , biochemistry , rna , gene
Adropin is a secreted polypeptide that has been demonstrated to play an important role in energy homeostasis and lipid metabolism. Signal transducer and activator of transcription 3 (STAT3) may promote the transcription of target genes including adropin. In the current study, we investigated the effect of adropin on glucose metabolism in diabetic rats and the mechanism that governs this effect was subsequently assessed.