Open Access<p>Resveratrol Prevents Cognitive Impairment in Type 2 Diabetic Mice by Upregulating Nrf2 Expression and Transcriptional Level</p>
Author(s) -
Xiaoxiao Wang,
Hui Fang,
Gang Xu,
Ying Yang,
Renfeng Xu,
Qiang Liu,
Xiangyu Xue,
J. Liu,
Hezhi Wang
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s243560
Subject(s) - morris water navigation task , resveratrol , hippocampal formation , streptozotocin , oxidative stress , neuroprotection , nissl body , endocrinology , medicine , hippocampus , western blot , water maze , biology , diabetes mellitus , pharmacology , pathology , staining , biochemistry , gene
This study aimed to determine whether the natural antioxidant resveratrol (RSV) prevents type 2 diabetes mellitus (T2DM)-induced cognitive impairment and to explore whether redox-associated factor nuclear factor erythroid 2-related factor 2 (Nrf2) plays a critical role in the neuroprotective effect of RSV.