Open Access<p>Early Left Ventricular Systolic Dysfunction Detected by Two-Dimensional Speckle-Tracking Echocardiography in Young Patients with Congenital Generalized Lipodystrophy</p>
Author(s) -
Christiane Bezerra Rocha Liberato,
Natália Bitar da Cunha Olegario,
Virgínia Oliveira Fernandes,
Ana Paula Dias Rangel Montenegro,
Grayce Ellen da Cruz Paiva Lima,
Lívia Aline de Araújo Batista,
Lívia Vasconcelos Martins,
Jaquellyne Gurgel Penaforte-Saboia,
Ivan Lucas Rocha Liberato,
Larissa Ferreira Lopes,
Catarina Brasil d’Alva,
Frederico Luís Braz Furtado,
Ricardo Luiz De Medeiros Lima,
Lúcia Helena Coelho Nóbrega,
Josivan Gomes Lima,
Renan Magalhães Montenegro Júnior
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s233667
Subject(s) - medicine , cardiology , ejection fraction , speckle tracking echocardiography , left ventricular hypertrophy , lipodystrophy , insulin resistance , diabetes mellitus , diastole , endocrinology , heart failure , insulin , blood pressure , family medicine , human immunodeficiency virus (hiv) , antiretroviral therapy , viral load
Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by the absence of functional adipocytes resulting in ectopic lipid storage, metabolic disorders and early cardiovascular disease. Two-dimensional speckle-tracking (2D-STE) allows the detection of early abnormalities in myocardial function. We aimed to evaluate myocardial deformation in a large sample of CGL patients using 2D-STE.