Open Access<p>Guava Leaf Extract Attenuates Insulin Resistance via the PI3K/Akt Signaling Pathway in a Type 2 Diabetic Mouse Model</p>
Author(s) -
Qiong Yang,
Yumei Wen,
Jing Shen,
Meimei Chen,
Jianghua Wen,
Zhengming Li,
Yao Liang,
Ning Xia
Publication year - 2020
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s231979
Subject(s) - insulin resistance , medicine , endocrinology , protein kinase b , insulin , pi3k/akt/mtor pathway , insulin receptor , diabetes mellitus , irs1 , type 2 diabetes , downregulation and upregulation , metformin , biology , signal transduction , biochemistry , gene
Insulin resistance is well known to exhibit essential effects on the progression of diabetes mellitus (DM). Guava leaf was also reported to exhibit anti-diabetic effects including decreasing blood glucose. Therefore, this present study aims to explore the role guava leaf extract (GLE) plays in insulin resistance and its mechanism of action via the PI3K/Akt signaling pathway.