Open Access<p>TNF-α (−308) Gene Polymorphism and Type 2 Diabetes Mellitus in Ethiopian Diabetes Patients</p>
Author(s) -
Birhanu Ayelign,
Meaza Genetu,
Tadelo Wondmagegn,
Gashaw Adane,
Markos Negash,
Nega Berhane
Publication year - 2019
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s229987
Subject(s) - diabetes mellitus , type 2 diabetes mellitus , polymorphism (computer science) , medicine , gene , tumor necrosis factor alpha , type 2 diabetes , genetics , biology , endocrinology , genotype
Type 2 diabetes mellitus (T2DM) is a metabolic disorder resulting from insulin insufficiency or function. Predisposing factors for T2DM are mainly genetic and environmental. Genetic polymorphism of cytokines like tumor necrosis factor-alpha (TNF-α) is suggestive of interference with insulin-sensitive glucose uptake and induces insulin resistance that ultimately could lead to T2DM. In this study, we assessed the effect of TNF-α (-308) G/A gene polymorphism and its association with the development of T2DM in an Ethiopian population.