Open Access<p>Dysregulation of DPP4 Is Associated with the AMPK/JAK2/STAT3 Pathway in Adipocytes Under Insulin Resistance Status and Liraglutide Intervention</p>
Author(s) -
Fangxiao Cheng,
Geheng Yuan,
Jing He,
Yimin Shao,
Junqing Zhang,
Xiaohui Guo
Publication year - 2019
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s229838
Subject(s) - ampk , insulin resistance , liraglutide , medicine , endocrinology , insulin , diabetes mellitus , microbiology and biotechnology , biology , kinase , protein kinase a , type 2 diabetes
Dipeptidyl peptidase 4 (DPP4) is one of the newly identified adipokines, which acts as paracrine in adipose tissue and as endocrine hormones in the liver, muscles and central nervous system. Expression of DPP4 was significantly upregulated in obese patients upon insulin resistance (IR) conditions, but the mechanism underlying the dysregulation of DPP4 remains unclear. This study aimed to investigate the DPP4 expression in adipose tissue and adipocytes under IR conditions or with liraglutide intervention, and explore the potential molecular mechanisms.