Open Access<p>lncRNA GAS5/miR-452-5p Reduces Oxidative Stress and Pyroptosis of High-Glucose-Stimulated Renal Tubular Cells</p>
Author(s) -
Chen Xie,
Weiling Wu,
Ainan Tang,
Na Luo,
Yanfei Tan
Publication year - 2019
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s228654
Subject(s) - pyroptosis , oxidative stress , western blot , chemistry , inflammation , transfection , gene knockdown , microbiology and biotechnology , apoptosis , biology , programmed cell death , biochemistry , immunology , gene
Diabetic nephropathy (DN) is the leading cause of end-stage renal failure worldwide. lncRNAs are demonstrated to improve the DN by changing the expression of miRNAs. This study was aimed to investigate the effect of lncRNA GAS5/miR-452-5p on the inflammation, oxidative stress and pyroptosis of high-glucose-induced renal tubular cells.