Open Access<p>Cdc42 Promotes ADSC-Derived IPC Induction, Proliferation, And Insulin Secretion Via Wnt/β-Catenin Signaling</p>
Author(s) -
Xiangyu Xiao,
Qidang Huang,
Xiaoqin Qian,
Jing Duan,
Xueqiao Jiao,
Longyuan Wu,
Li Jun,
Xing-Ning Lai,
Yubo Shi,
Likuan Xiong
Publication year - 2019
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s226055
Subject(s) - wnt signaling pathway , cdc42 , biology , microbiology and biotechnology , islet , signal transduction , endocrinology , insulin
Type 1 diabetes mellitus (T1DM) is characterized by irreversible islet β cell destruction. Accumulative evidence indicated that Cdc42 and Wnt/β-catenin signaling both play a critical role in the pathogenesis and development of T1DM. Further, bio-molecular mechanisms in adipose-derived mesenchymal stem cells (ADSCs)-derived insulin-producing cells (IPCs) remain largely unknown. Our aim was to investigate the underlying mechanism of Cdc42/Wnt/β-catenin pathway in ADSC-derived IPCs, which may provide new insights into the therapeutic strategy for T1DM patients.