Open Access<p>Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway</p>
Author(s) -
Tian-Kui Ma,
LiYan Xu,
Ling-Xu Lu,
Xu Cao,
Xin Li,
Lulu Liu,
Xu Wang,
Qiuling Fan
Publication year - 2019
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s222323
Subject(s) - nox4 , angiotensin ii , endocrinology , diabetic nephropathy , medicine , blot , kidney , urotensin ii , glomerulosclerosis , chemistry , fibronectin , oxidative stress , western blot , immunohistochemistry , inflammation , creatinine , receptor , nadph oxidase , extracellular matrix , biochemistry , proteinuria , gene
This study aimed to investigate whether ursolic acid (UA) mitigates renal inflammation, oxidative stress and fibrosis by regulating the angiotensin II type 1 receptor-associated protein (ARAP1)/angiotensin II type 1 receptor (AT1R) signaling pathway and subsequently alleviating renal damage.