Open Access<p>NLRP3 inflammasome promotes diabetes-induced endothelial inflammation and atherosclerosis</p>
Author(s) -
Zhang Wan,
Ye Fan,
Xiaojun Liu,
Jie Xue,
Zhenhua Han,
Canzhan Zhu,
Xinhong Wang
Publication year - 2019
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s222053
Subject(s) - inflammasome , inflammation , diabetes mellitus , medicine , endocrinology , gene knockdown , cell adhesion molecule , umbilical vein , peripheral blood mononuclear cell , immunology , chemistry , in vitro , apoptosis , biochemistry
NLRP3 inflammasome can be activated by high glucose and links inflammation and metabolic disease. This study aimed to investigate the role of NLRP3 inflammasome in hyperglycemia-induced endothelial inflammation and diabetic atherosclerosis.