Open Access<p>AdipoRon Alleviates Free Fatty Acid-Induced Myocardial Cell Injury Via Suppressing Nlrp3 Inflammasome Activation</p>
Author(s) -
Zhang You-zhi,
Yulin Zhang,
Qi Huang,
Cong Huang,
Zhilong Jiang,
Fei Cai,
Jianfen Shen
Publication year - 2019
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s221841
Subject(s) - inflammasome , lipotoxicity , viability assay , chemistry , adiponectin , caspase 1 , microbiology and biotechnology , cell , biology , endocrinology , biochemistry , receptor , insulin , insulin resistance
Hypoadiponectinemia is a high risk factor for type 2 diabetes and cardiovascular disease. Although adiponectin is a protective molecule in cardiovascular diseases, it is hampered due to short plasma half-life and high cost of production. This study aimed to investigate whether AdipoRon, a small-molecule adiponectin receptor agonist, alleviated saturated free fatty acids such as palmitic acid (PA)-induced cardiomyocyte injury by suppressing Nlrp3 inflammasome activation.