Open Access<p>Plant-derived oleanolic acid ameliorates markers associated with non-alcoholic fatty liver disease in a diet-induced pre-diabetes rat model</p>
Author(s) -
Mlindeli Gamede,
Lindokuhle Mabuza,
Phikelelani Ngubane,
Andile Khathi
Publication year - 2019
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s218626
Subject(s) - medicine , endocrinology , diabetes mellitus , oleanolic acid , fatty liver , oxidative stress , type 2 diabetes , metformin , very low density lipoprotein , cholesterol , lipoprotein , disease , pathology , alternative medicine
The increased prevalence of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) patients is becoming a worldwide health burden. Studies have indicated, however, that the onset of NAFLD occurs during pre-diabetes, a condition that often precedes the onset of T2DM. Oleanolic acid has been reported to improve glucose homeostasis in diet-induced pre-diabetes; however, the effects of this triterpene on liver function have not been evaluated.