Open Access<p>IL6R inhibits viability and apoptosis of pancreatic beta-cells in type 2 diabetes mellitus via regulation by miR-22 of the JAK/STAT signaling pathway</p>
Author(s) -
Xinhua Wu,
Tao Yu,
Ning Ji,
Yujie Huang,
Lingcheng Gao,
Wen Shi,
Yan Yan,
Hang Li,
Liming Ma,
Kede Wu,
Zhen Wu
Publication year - 2019
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s211700
Subject(s) - viability assay , apoptosis , microrna , signal transduction , downregulation and upregulation , transfection , cancer research , biology , microbiology and biotechnology , cell culture , gene , biochemistry , genetics
Type 2 diabetes mellitus (T2DM) is a common disease of harming to people's health. MicroRNAs have recently been considered as key regulators of many biological processes, such as cell proliferation, migration and apoptosis. However, the effect of miR-22 expression by targeting IL6 receptor (IL6R) in T2DM and potential molecular mechanism involved remains to be elucidated. The present study aimed to explore the regulatory mechanism of miR-22 by targeting IL6R in pancreatic beta-cells viability and apoptosis of T2DM.