Open Access<p>Estrogen receptor inhibition enhances cold-induced adipocyte beiging and glucose tolerance</p>
Author(s) -
Kfir Lapid,
Ajin Lim,
Eric D. Berglund,
Yue Lu
Publication year - 2019
Publication title -
diabetes, metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s190752
Subject(s) - fulvestrant , endocrinology , medicine , estrogen receptor , estrogen , adipocyte , thermogenesis , estrogen receptor alpha , biology , chemistry , adipose tissue , cancer , breast cancer
Low estrogen states, exemplified by postmenopausal women, are associated with increased adiposity and metabolic dysfunction. We recently reported a paradox, in which a conditional estrogen receptor-alpha (ERα) mutant mouse shows a hyper-metabolic phenotype with enhanced brown/beige cell formation ("browning/beiging").