Open AccessExploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification
Author(s) -
Wan Shu,
Ziwei Wang,
Rong Zhao,
Rui Shi,
Jun Zhang,
Wei Zhang,
Hongbo Wang
Publication year - 2022
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s361955
Subject(s) - kegg , in vitro , docking (animal) , computational biology , apoptosis , chemistry , gene , biology , biochemistry , pharmacology , gene expression , transcriptome , medicine , nursing
Endometrial cancer (EC) is one of the most common gynecological malignancies, especially in postmenopausal women. Echinacoside (ECH) is a major natural bioactive ingredient derived from Cistanches Herba and Echinacea that has a variety of pharmacological effects. However, the efficacy and the mechanism of ECH against EC have not been elucidated yet.