Open AccessKnee Osteoarthritis Therapy: Recent Advances in Intra-Articular Drug Delivery Systems
Author(s) -
Luoyang Ma,
Xiaoyan Zheng,
Rui Li,
Aijuan Sun,
Jintong Song,
Zhiqiang Ye,
Dahong Liang,
Min Zhang,
Jia Tian,
Xin Zhou,
Liao Cui,
Yuyu Liu,
Yan Zhi Liu
Publication year - 2022
Publication title -
drug design, development and therapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s357386
Subject(s) - osteoarthritis , medicine , drug delivery , intra articular , pharmacotherapy , alternative medicine , pathology , chemistry , organic chemistry
Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a common strategy and its therapeutic effects depend mainly on the efficacy of the drug-delivery system used for OA therapy. Different types of IA drug-delivery systems, such as microspheres, nanoparticles, and hydrogels, have been rapidly developed over the past decade to improve their therapeutic effects. With the continuous advancement in OA mechanism research, new drugs targeting specific cell/signaling pathways in OA are rapidly evolving and effective drug delivery is critical for treating OA. In this review, recent advances in various IA drug-delivery systems for OA treatment, OA targeted strategies, and related signaling pathways in OA treatment are summarized and analyzed based on current publications.