Open AccessInvolvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease
Author(s) -
YiYu Qi,
Heng Xia,
ZengYing Yao,
ShuYue Qu,
Ping-Yuan Ge,
Xin Zhao,
Sai-Jia Ni,
Rui Guo,
NianYun Yang,
Qichun Zhang,
Hua Zhu
Publication year - 2022
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s357061
Subject(s) - sphingolipid , lactosylceramide , ceramide , sphingosine , sphingomyelin , microglia , biochemistry , chemistry , pharmacology , microbiology and biotechnology , biology , immunology , enzyme , inflammation , cholesterol , apoptosis , receptor
Abnormal sphingolipid metabolism is closely related to the occurrence and development of Alzheimer's disease (AD). With heat-clearing and detoxifying effects, Huanglian Jiedu decoction (HLJDD) has been used to treat dementia and improve learning and memory impairments.