Open AccessPalmatine Protects Against MSU-Induced Gouty Arthritis via Regulating the NF-κB/NLRP3 and Nrf2 Pathways
Author(s) -
Juanjuan Cheng,
Xingdong Ma,
Gaoxiang Ai,
Qiuxia Yu,
Xiaoying Chen,
F. Yan,
Yucui Li,
Jianhui Xie,
Ziren Su,
Qipeng Xie
Publication year - 2022
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s356307
Subject(s) - superoxide dismutase , oxidative stress , arthritis , chemistry , western blot , pharmacology , tumor necrosis factor alpha , malondialdehyde , inflammation , glutathione , iκbα , proinflammatory cytokine , nf κb , signal transduction , immunology , biochemistry , medicine , gene , enzyme
Gouty arthritis could be triggered by the deposition of monosodium uric acid (MSU) crystals. Palmatine (PAL), a protoberberine alkaloid, has been proven to possess compelling health-beneficial activities. In this study, we aimed to explore the effect of PAL on LPS plus MSU crystal-stimulated gouty arthritis in vitro and in vivo.