Open AccessNano Sized Hydroxyapatite-Polylactic Acid-Vancomycin in Alleviation of Chronic Osteomyelitis
Author(s) -
Xiaoyi Lv,
Dongming Zhou,
Xingming Sun,
Ze Zhao
Publication year - 2022
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s356257
Subject(s) - polylactic acid , biocompatibility , chemistry , osteoblast , bone marrow , osteomyelitis , nuclear chemistry , materials science , biomedical engineering , in vitro , medicine , immunology , biochemistry , polymer , organic chemistry
Vancomycin (VAN) is effective in inhibiting inflammatory reactions in chronic osteomyelitis (CO), while nano-hydroxyapatite (nHA) can effectively address the poor biocompatibility and high brittleness of ordinary HA and better repair bone defects. Therefore, the efficacy of nHA combined with VAN for CO with bone defects deserves further discussion.