Open AccessClotrimazole Inhibits HCC Migration and Invasion by Modulating the ERK-p65 Signaling Pathway
Author(s) -
Xudong Li,
Jie Gao,
Yaohui Sun,
Feng Zhang,
Wenzhi Guo,
Shuijun Zhang
Publication year - 2022
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s354205
Subject(s) - mapk/erk pathway , clotrimazole , cancer research , kinase , epithelial–mesenchymal transition , hepatocellular carcinoma , cell migration , dephosphorylation , mek inhibitor , metastasis , chemistry , phosphorylation , cancer , biology , medicine , microbiology and biotechnology , cell , phosphatase , biochemistry , antifungal
Hepatocellular carcinoma (HCC), has a very high mortality rate and is the most common type of liver cancer. Clotrimazole, a traditional antifungal drug, has garnered considerable attention as a therapeutic strategy for HCC. However, its effects against the migration and invasion of HCC cells as well as the associated underlying mechanisms remain unclear. Therefore, in this study, we investigated its effects on HCC and attempted to elucidate the underlying molecular mechanisms.