Open AccessNintedanib Treatment After Ovulation is an Effective Therapeutic Strategy for the Alleviation of Ovarian Hyperstimulation Syndrome (OHSS) in a Mouse Model
Author(s) -
Shutian Jiang,
Wenzhi Li,
Xinxi Zhao,
Li Chen,
Yanping Kuang
Publication year - 2022
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s351292
Subject(s) - ovarian hyperstimulation syndrome , nintedanib , medicine , ovulation induction , ovulation , endocrinology , gynecology , pharmacology , hormone , biology , pregnancy , in vitro fertilisation , genetics , idiopathic pulmonary fibrosis , lung
Ovarian hyperstimulation syndrome (OHSS) is a serious complication of controlled ovarian hyperstimulation. In this study, we hope to explore whether nintedanib, a tyrosine kinase inhibitor, can inhibit OHSS by blocking signaling of vascular endothelial growth factor in a mouse model. Considering that nintedanib been approved for the treatment of some diseases. We believe that nintedanib has important potential in the treatment of OHSS.