Open AccessDesign, Synthesis, and Biological Evaluation of 2-Anilino-4-Triazolpyrimidine Derivatives as CDK4/HDACs Inhibitors
Author(s) -
Suhua Wang,
Siyuan Han,
Weiyan Cheng,
Ruoyang Miao,
Shasha Li,
Xin Tian,
Quancheng Kan
Publication year - 2022
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s351049
Subject(s) - chemistry , pharmacophore , cyclin dependent kinase 6 , cell growth , cell cycle , cyclin dependent kinase , ic50 , cell cycle checkpoint , growth inhibition , cell culture , cyclin dependent kinase 2 , kinase , hdac1 , hdac8 , biochemistry , histone deacetylase , apoptosis , biology , in vitro , histone , genetics , gene
To enhance the cytotoxicities of our obtained CDK4 inhibitors and get CDK4/HDACs inhibitors with potent enzymatic inhibitory and anti-proliferative activities.