Open AccessMolecular Mechanism Underlying Effects of Wumeiwan on Steroid-Dependent Asthma: A Network Pharmacology, Molecular Docking, and Experimental Verification Study
Author(s) -
Mingsheng Lyu,
Yahui Wang,
Qiuyi Chen,
Jingbo Qin,
Dan Hou,
Songming Huang,
Dongmei Shao,
Xuefeng Gong,
Guirui Huang,
Shiyu Zhang,
Zhijie Zhang,
Hongsheng Cui
Publication year - 2022
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s349950
Subject(s) - kegg , docking (animal) , pharmacology , biology , computational biology , in silico , steroid , bioinformatics , medicine , gene expression , gene , genetics , biochemistry , gene ontology , nursing , hormone
Steroid-dependent asthma (SDA) is characterized by oral corticosteroid (OCS) resistance and dependence. Wumeiwan (WMW) showed potentials in reducing the dose of OCS of SDA patients based on our previous studies.