Open AccessThe Therapeutic Effect and the Possible Mechanism of C-Phycocyanin in Lipopolysaccharide and Seawater-Induced Acute Lung Injury
Author(s) -
Leifang Zhang,
Deyi Kong,
Jiuzuo Huang,
Qiongfen Wang,
Lilin Shao
Publication year - 2022
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s347772
Subject(s) - lipopolysaccharide , seawater , mechanism (biology) , phycocyanin , lung , medicine , chemistry , pharmacology , intensive care medicine , microbiology and biotechnology , biology , immunology , bacteria , cyanobacteria , ecology , physics , genetics , quantum mechanics
Seawater drowning-induced acute lung injury (ALI) is a severe clinical condition characterized by increased alveolar-capillary permeability, excessive inflammatory response, and refractory hypoxemia. C-phycocyanin (C-PC), a biliprotein found in blue-green algae such as spirulina platensis, is widely used in the food and dietary nutritional supplement fields due to its beneficial pharmacological effects. Previous studies have revealed that C-PC has anti-inflammatory, antioxidant, and anti-apoptotic activities.