Open AccessBerberine Influences the Survival of Fat Grafting by Inhibiting Autophagy and Apoptosis of Human Adipose Derived Mesenchymal Stem Cells
Author(s) -
Haijun Pang,
Yongting Zhou,
Jie Wang,
Hao Wu,
Xueyi Liu,
Feng Gao,
Zhibo Xiao
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s337215
Subject(s) - autophagy , mesenchymal stem cell , adipose tissue , apoptosis , pi3k/akt/mtor pathway , microbiology and biotechnology , ampk , cancer research , transplantation , chemistry , stromal vascular fraction , programmed cell death , angiogenesis , stem cell , pharmacology , biology , medicine , kinase , protein kinase a , biochemistry
Human adipose-derived mesenchymal stem cells (ADSCs) have the potential to be applied to solid organ treatments. However, tissue regeneration is limited by the death of transplanted cells. Ischemia is the main cause of the poor outcome. This study aimed to investigate the effect of berberine (BBR) on ADSCs after fat grafting.