Open AccessAntifungal Effects and Potential Mechanisms of Benserazide Hydrochloride Alone and in Combination with Fluconazole Against Candida albicans
Author(s) -
Xueqi Chen,
Jiyong Wu,
Lei Sun,
Jing Nie,
Shan Su,
Shujuan Sun
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s336667
Subject(s) - candida albicans , fluconazole , microbiology and biotechnology , galleria mellonella , in vivo , corpus albicans , broth microdilution , candida glabrata , in vitro , biofilm , pharmacology , biology , virulence , chemistry , minimum inhibitory concentration , antimicrobial , antifungal , biochemistry , bacteria , gene , genetics
The resistance of C. albicans to traditional antifungal drugs brings a great challenge to clinical treatment. To overcome the resistance, developing antifungal agent sensitizers has attracted considerable attention. This study aimed to determine the anti- Candida activity of BEH alone or BEH-FLC combination and to explore the underlying mechanisms.