Open AccessThe Effect of Metformin on the Proliferation, Apoptosis and CD133 mRNA Expression of Colon Cancer Stem Cells by Upregulation of miR 342-3p
Author(s) -
Yaqin Zhang,
Ruofei Chen,
Lili Deng,
Zongwen Shuai,
Mingwei Chen
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s336490
Subject(s) - microrna , apoptosis , flow cytometry , transfection , downregulation and upregulation , cancer research , viability assay , biology , andrology , cell culture , immunology , medicine , gene , biochemistry , genetics
To explore whether metformin (MET) can affect the biological behaviour and CD133 mRNA expression of CD133 + colon cancer stem cells (CCSCs) through miR-342-3p.