Open AccessMethylcobalamin Protects Melanocytes from H2O2-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway
Author(s) -
Ran An,
Dong Liu,
Yingying Dong,
Qiuyun She,
Ting Zhou,
Xiaoqi Nie,
Ronghua Pan,
Yansha Deng
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s336066
Subject(s) - oxidative stress , superoxide dismutase , chemistry , reactive oxygen species , microbiology and biotechnology , flow cytometry , apoptosis , melanocyte , biochemistry , biology , cancer research , melanoma
Oxidative stress is considered a major determinant in the pathogenesis of vitiligo. Methylcobalamin (MeCbl) is an activated form of vitamin B12 that regulates inflammatory factors, counters oxidative stress, and reduces apoptosis in many disease models. However, the specific mechanism of MeCbl repigmentation against vitiligo is unknown. In this study, we explored the effect of MeCbl on melanocytes following hydrogen peroxide (H 2 O 2 )-induced oxidative stress.