Open AccessA New Strategy for the Rapid Identification and Validation of the Direct Targets of Aconitine-Induced Cardiotoxicity
Author(s) -
Jinxia Wei,
Simiao Fan,
Hongxin Yu,
Lexin Shu,
Yubo Li
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s335461
Subject(s) - aconitine , cardiotoxicity , pharmacology , chemistry , docking (animal) , drug discovery , computational biology , toxicity , biochemistry , medicine , biology , nursing , organic chemistry
The interaction of small molecules with direct targets constitutes the molecular initiation events of drug efficacy and toxicity. Aconitine, an active compound of the Aconitum species, has various pharmacological effects but is strongly toxic to the heart. The direct targets of aconitine-induced cardiotoxicity remain unclear.