Open AccessA Network Pharmacology Study on the Molecular Mechanism of Protocatechualdehyde in the Treatment of Diabetic Cataract
Author(s) -
Xiao Cheng,
Zhimin Song,
Xin Wang,
XU Shan-shan,
Liming Dong,
Jie Bai,
Guangyao Li,
Chao Zhang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s334693
Subject(s) - kegg , signal transduction , mechanism (biology) , computational biology , chemistry , pharmacology , bioinformatics , medicine , biology , gene , gene expression , biochemistry , gene ontology , philosophy , epistemology
Protocatechualdehyde (PCA) is a phenolic compound found in the roots of Salvia miltiorrhiza with anti-proliferative and antioxidant activities. At present, there are few studies on protocatechualdehyde against diabetic cataract (DC), and there is also lack of systematic research on the mechanism of protocatechualdehyde. Therefore, this study tried to comprehensively clarify the targets and complex mechanisms of PCA against DC from the perspective of network pharmacology.