Open AccessEnhancement of Cancer Chemotherapeutic Efficacy via Bone-Targeted Drug Delivery Carrier in Bone Metastases
Author(s) -
Xinghe Xue,
Jiangyong Yu,
Fengfeng Lu,
Hongyi Jiang,
Xiangyang Wang
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 1177-8881
DOI - 10.2147/dddt.s333999
Subject(s) - in vivo , doxorubicin , drug delivery , pharmacokinetics , biodistribution , flow cytometry , cancer research , drug , in vitro , confocal microscopy , cancer , chemistry , chemotherapy , pharmacology , biomedical engineering , materials science , medicine , nanotechnology , immunology , biology , biochemistry , microbiology and biotechnology
Bone metastases are common in malignant tumors, especially for the advanced cancers. Chemotherapy is an important treatment in clinic, but the application is limited due to the severe adverse reactions. We try to design bone-targeted drug delivery systems (DDS) for the delivery of chemotherapeutic drugs in bone metastatic carcinoma.