Open AccessUnravelling the Protective Effects of Emodin Against Cyclophosphamide Induced Gonadotoxicity in Male Wistar Rats
Author(s) -
Yinhua Wang,
Zhaoling Zou,
Amit Jaisi,
Opeyemi Joshua Olatunji
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s333383
Subject(s) - oxidative stress , spermatogenesis , sperm , proinflammatory cytokine , sperm motility , toxicity , testosterone (patch) , endocrinology , cyclophosphamide , medicine , andrology , pharmacology , biology , inflammation , chemotherapy
Over the past few decades, cyclophosphamide (CP) has been extensively used as a broad-spectrum alkylating agent for the treatment of various cancers and solid tumors. However, the therapeutic actions on CP are not limited to only cancer cells, as it simultaneously exerts significant toxicities on healthy cells through the instigation of oxidative stress and oxidative damages. CP induced testicular toxicity is associated with impaired spermatogenesis, reduced sperm functionality, reproductive hormone and testicular weight. This study was aimed at unravelling the protective effects of emodin (EMD) on testicular toxicity following CP treatment.