Open AccessKetamine Induces Ferroptosis of Liver Cancer Cells by Targeting lncRNA PVT1/miR-214-3p/GPX4
Author(s) -
Guannan He,
Naren two ya Bao,
Shuang Wang,
Man Xi,
Tian-Hao Zhang,
Fengshou Chen
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s332847
Subject(s) - gpx4 , viability assay , cell growth , cancer research , lipid peroxidation , chemistry , cancer cell , microbiology and biotechnology , cell , cancer , biology , glutathione peroxidase , biochemistry , oxidative stress , superoxide dismutase , genetics
Liver cancer ranks the top four malignant cancer type worldwide, which needs effective and safe treatment. Ferroptosis is a novel form of regulated cell death driven by iron-dependent lipid peroxidation and has been regarded as a promising therapeutic target for cancers. In this work, we aimed to study the effects of anesthetic ketamine on proliferation and ferroptosis of liver cancer.