Open AccessSynthesis of Novel Pinocembrin Amino Acid Derivatives and Their Antiaging Effect on Caenorhabditis elegans via the Modulating DAF-16/FOXO
Author(s) -
Wenqi Wang,
Xin Feng,
Yu Du,
Cen Liu,
Xinxin Pang,
Kunxiu Jiang,
Xirui Wang,
Yonggang Liu
Publication year - 2021
Publication title -
drug design, development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s330223
Subject(s) - pinocembrin , caenorhabditis elegans , amino acid , biochemistry , microbiology and biotechnology , chemistry , cytosol , oxidative stress , biology , antioxidant , gene , enzyme , flavonoid
Pinocembrin is a dihydroflavonoid, which is widely found in several plant species. Although pinocembrin has good pharmacological activity, it has poor water solubility and low bioavailability. Therefore, we have modified the structure of pinocembrin with a combination of different amino acids to solve this problem. Moreover, the effect of the antiaging activity of them has not been explored. We aim to investigate the effect of pinocembrin and its amino acid derivatives on the aging of Caenorhabditis elegans .